Miscellaneous intranasal medications
The number of potential applications for intranasal medications is enormous. Potential uses that may enhance or provide alternative treatment modalities include headache therapy,[1-15, 32] anti-nausea medication delivery in patients intolerant of oral medications and patients suffering from diabetic gastroparesis,[16-19, 44] chronic pain therapy,[20-25] insulin therapy (avoid multiple daily shots),[26,37] vaccine administration (enhance immune response by delivery via a more natural exposure route),[27-29] antipsychotic medications (reduce chance or injury to patient and provider),[45,46] prevention of abnormal nasal blood vessel growth (Avastin) and even the delivery of medications and drug antidotes such as hydroxocobalamin (antidote to cyanide poisoning)[11, 30, 31]. Another topic investigated in intranasal B-2 agonists for asthma - something that could use further investigation. More recently interest is developing on delivery of a number of peptides and other drugs to the nose for direct transport into the brain to treat neurodegenerative disorders such as Alzheimer's (click here for an article on the topic). Intranasal insulin is being investigated for treatment of neurodegenerative disorders such as Alzheimer's disease. IN ketamine is becoming an area of significant research interest for the treatment of bipolar disease and major depressive disorder with early results suggesting a strong and prolonged antidepressant effect following a single subdissociative dose (50 mg) of ketamine[34, 42-43, 47, 48], while Intranasal oxytocin is being actively investigated for many psychiatric conditions including alcohol withdrawal, anorexia nervosa, PTSD, autism, anxiety disorders, pain sensation and schizophrenia.[35,38-41]
Some of these concepts are fully developed and commercially available pharmaceutical products are already available on the market such as intranasal dihydroergotamine for headaches and nasal vaccines for influenza.[27-29] Other concepts, such as intranasal hydroxocobalamin are purely conjecture and may or may not be viable concepts.The area of intranasal medication delivery provides a huge opportunity for research – both for specifically developed pharmaceutical drugs designed for intranasal treatment, as well as for investigating off label uses of commonly available generic medications.
Link to separate web site listing ongoing intranasal research into many drugs - insulin, viral particles, glucagon, flu, etc - click here
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