Intranasal Drug Delivery - Full
Length Peer Reviewed Medical Articles:
Please see bibliography section for abstracts of
all references listed in this web site. This section contains full
articles and web links to full articles.
NASAL MEDICATIONS FOR SEIZURE THERAPY:
Intranasal Midazolam for seizures
Holsti, Prehospital intranasal midazolam for the treatment of pediatric
seizures, Ped Emerg Care 2007 (click here for web site link)
Klein-Kremer, Intranasal midazolam for the treatment of seizures in
children in the Emergency setting, Isreali J EM 2007 (click here) -
PDF 0.13 MB
Lahat, IN midazolam for seizures, BMJ 2000 (click here) - PDF 0.25
MB
Krykou, IN midazolam for community seizure therapy, Epilepsy Australia
2006 (click here) - PDF 0.44 MB
Segal, An alternate route of drug administration in acute convulsions,
IMAJ 2000 (click here) - PDF 0.09 MB
Bhattacharyya, Intranasal midazolam vs rectal diazepam in acute
childhood seizures, Pediatr Neurol 2006
Whitesell, IN midazolam vs rectal diazepam - synthesis of the evidence,
J Ped Healthcare 2009 abstract
Ma, Clinical Guidelines on Management of Prolonged Seizures, HK J
Paediatrics 2010 - MS word file
Intranasal Lorazepam for seizures
Ahmad, Intranasal lorazepam vs intramuscular paraldehyde for prolonged
convulsions, Lancet 2006
French JA.. Benzo vs Benzo: And the winner is.. Epilepsy Curr
2011;11(5):143-144
Lissauer, S., J. Kenny, et al. (2015). "Buccal, intranasal or
intravenous lorazepam for the treatment of acute convulsions in children
in Malawi: An open randomized trial." African Journal o f Emergency
Medicine 5:
120-126.
NASAL MEDICATIONS FOR SEDATION
Intranasal Midazolam for sedation
Al-Rakaf, Intra-nasal midazolam for conscious sedation of pediatric
dental patients, Int J Ped Dentistry 2001 (click here) - PDF
0.32 MB
Manley, IN and IV midazolam for sedation in adults with learning
disability, Br Dent Journal 2008. - PDF 0.18 MB
Morgans-Perri, MAD for IN midazolam pre-op, J Perianesthtic Nursing 2009
abstract
Koppal R, Adarsh ES, Ambi U, Anilkumar G. Comparison of the
midazolam transnasal atomizer and oral midazolam for sedative
premedication in paediatric cases. JCDR 2011;5:932-934
Intranasal ketamine for sedation
Kazemi, Intranasal ketamine versus intranasal midazolam for preoperative
sedation in children, Pak J Med Sci 2005 (click here) - PDF 0.12 MB
Gharde, IN
ketamine and IN midazolam for sedation of children with Tetralogy of
Fallot, Ann Cardiac Anesth 1996 (click for web site link)
Pandey, R. K., S. K. Bahetwar, et al. (2011). "A comparative evaluation
of drops versus atomized administration of intranasal ketamine for the
procedural sedation of young uncooperative pediatric dental patients: a
prospective crossover trial." J Clin Pediatr Dent
36(1): 79-84.
Buonsenso, IN ketamine and midazolam for pediatric gastric aspiration,
BMC Peds 2014
Intranasal Dexmedetomidine for sedation and premedication before
anesthesia
Yuen,
Sedative effects of intranasal dexmetetomidine, Anesth Analg 2007
Sundaram, A comparative evaluation of intranasal dexmedetomidine and
intranasal midazolam for premedication in children: A double blind RCT.
JIDA 2011;5(7):777-781. (Free Access)
Hitt, IN sufentanil and DME for pediatric dental sedation, Pharmaceutics
2014 (open access)
Sulton, The use of intranasal dexmedetomidine for pediatric sedation: A
report from the pediatric sedation research consortium. 2014 abstract
Intranasal clonidine for sedation and premedication before
anesthesia
NASAL MEDICATIONS FOR PAIN CONTROL
Sokoloff, Time to analgesia reduces ED LOS, BMJOpen 2014 open access
Intranasal Morphine for pain
Fitzgibbon, Nasal Morphine for breakthrough pain, Pain 2003 (click
here) - PDF 0.15 MB
Maroli, IN ketorolac for dental pain, J INt Oral 2014 open access
Intranasal Fentanyl for pain
Borland, A randomized controlled trial comparing intranasal fentanyl to
intravenous morphine for managing acute pain in children in the
emergency department, Ann Emerg Med 2007 (click here for web site link)
Rickard, A randomized controlled trial of intranasal fentanyl vs
intravenous morphine for analgesia in the prehospital setting, 2007
(click here for web site link)
Borland, Intranasal fentanyl vs oral morphine prior to dressing changes
for pediatric burns, Burns 2005
Finn,
RCT of intranasal fentanyl vs oral morphine prior to dressing changes in
adult burn unit, Burns 2004
Striebel, Intranasal fentanyl PCINA to treat post operative pain, Anesth
Analg 1996 (click here for web site link)
McLean, IN fentanyl use in ski resort, WMJ 2009
Chaplin, Instanyl for breakthrough pain, Prescriber 2010
Prommer, Intranasal fentanyl for pain control, current status with focus
on patient preference. Patient preference and adherence 2011
Belkouch, A., S. Zidouh, et al. (2015). "Does intranasal fentanyl
provide efficient analgesia for renal colic in adults?" Pan Afr
Med J 20: 407.
Intranasal Sufentanil for pain
Heshmati, Intranasal sufentanil for postoperative pain control in lower
abdominal pediatric surgery, IJPT 2006 (click here) - PDF 0.14 MB
Matheiu, Intranasal sufentanil is effective for postoperative analgesia
in adults, Can J Anaesthesia 2006 (click here) - PDF 0.32 MB
Helmers, Comparison of intravenous and intranasal sufentanil absorption
and sedation, Can J Anaesth 1989 (click here) - PDF 0.39 MB
Jackson, Intranasal sufentanil for breakthrough pain - preliminary
trial, J Pain and Symptom Management 2002
Liang, IN sufentanil or fentanyl for emergence agitation, Pak J Sci 2014
open access
Intranasal Diamorphine for pain
Kendall, Multicenter RCT of nasal diamorphine for analgesia in children
and teenagers with clinical fractures, BMJ 2001 (click here) - PDF
0.28 MB
Atkinson, Pain management and sedation for children seen in the
emergency room, BMJ 2009
NHS IN diamorphine protocol
2010
British association for emergency medicine pediatric pain protocol (click here).
Intranasal Ketamine for pain
Riediger C, Haschke M, Bitter C, et al. The analgesic effect of combined
treatment with intranasal S-ketamine and intranasal midazolam compared
with morphine patient-controlled analgesia in spinal surgery patients: a
pilot study. J Pain Res 2015;8:87-94.
NASAL MEDICATIONS FOR TREATING OPIATE AND
BENZODIAZEPINE INDUCED SEDATION
Intranasal Naloxone (Narcan)
Barton, Intranasal naloxone as a needleless alternative for treatment of
opiate overdose in the prehospital setting, J Emerg Med 2005 (Click here
for web site link)
Kelly, A
randomized trial of intranasal versus intramuscular naloxone for
prehospital treatment of suspected opiate overdose, Med J Aust 2005
(click here) - PDF 0.23 MB
Kerr, Effectiveness and safety of IN naloxone
versus IM naloxone for treatment of heroin overdoses, Addiction
2009
Maryland House bill 368 approving home use of IN naloxone to reduce
heroin overdose deaths (click here) - (PDF)
Doe-Simkins, M., et al., Saved by the nose: bystander-administered intranasal naloxone
hydrochloride for opioid overdose. Am J Public Health, 2009
Project Lazarus
Kim, Expanded access to naloxone, Am J Public Health 2009
Dasgupta, Opioid OD - a prescription for harm prevention, Am J Lifestyle
Med 2009
Wermeling, Opioid Harm Reduction strategies: Expanding access to
intranasal naloxone, Pharmacotherapy 2010
Sabzghabaee,
A. M., N. Eizadi-Mood, et al. (2014). "Naloxone therapy in opioid
overdose patients: intranasal or intravenous? A randomized clinical
trial." Arch Med Sci 10(2):
309-314.
Davis, C.S., et al., Expanded
access to naloxone among firefighters, police officers, and emergency
medical technicians in Massachusetts. Am J Public Health, 2014.
104(8): p. e7-9.
Doe-Simkins, M., et al., Overdose
rescues by trained and untrained participants and change in opioid use
among substance-using participants in overdose education and naloxone
distribution programs: a retrospective cohort study. BMC Public
Health, 2014. 14: p. 297.
Samuels, E., Emergency department
naloxone distribution: a rhode island department of health, recovery
community, and emergency department partnership to reduce opioid
overdose deaths. R I Med J (2013), 2014.
97(10): p. 38-9.
Wagner, K.D., et al., "I felt like
a superhero": the experience of responding to drug overdose among
individuals trained in overdose prevention. Int J Drug Policy, 2014.
25(1): p. 157-65. - go to
the end of the series for this document
W.H.O. (World Health Organization) 2014 recommendations regarding
Community management of opioid overdose - download the PDF
Burris, Stopping an invisible epidemic - legal issues related to
naloxone distribution, Temple Law 2009
Hammet, Pharmacies as providers of expanded health access for PWID, BMC
Health 2014 Open access
Doyon, S., S. E. Aks, et al. (2014). "Expanding access to naloxone in
the United States." J Med Toxicol 10(4): 431-434.
Intranasal Flumazenil (Anexate, Romazicon)
Heard, C., P. Creighton, and J. Lerman,
Intranasal flumazenil and naloxone
to reverse over-sedation in a child undergoing dental restorations.
Paediatr Anaesth, 2009.
NASAL MEDICATIONS FOR EPISTAXIS
Krempl, Intranasal oxymetazoline for the treatment of epistaxis, Ann
Otol Rhinol Laryngol 1995
NASAL MEDICATIONS FOR TOPICAL ANESTHESIA AND
VASOCONTRICTION
Intranasal vasoconstrictor articles
Intranasal anesthetic articles
VHA and the
National center for patient safety guide to the use of topical
anesthetics (click here) - PDF 0.2 MB
Wolfe, Atomized lidocaine prior to NG tube placement, Ann Emerg Med 2000
NASAL MEDICATIONS FOR TREATMENT OF HYPOGLYCEMIA
Intranasal glucagon articles
Pontiroli, Intranasal glucagon raises blood glucose concentrations in
healthy volunteers, BMJ 1983 (click here) - PDF 0.47 MB
DISCUSSIONS OF OFF LABEL MEDICATION USAGE
Tomaszewski, Off-Label: Just what the doctor ordered, J Medical
Toxicology 2006 (click here) - PDF 0.13 MB
NASAL MEDICATION REVIEWS AND MISCELLANEOUS TOPICS
Review articles
Goldman, Intranasal drug delivery in children, Curr Drug Therapy 2006 (click
here) - PDF 0.15 MB
Stanley, Anesthesia for the 21st Century, BUMC Proceedings 2000 (click
here) - PDF 0.05 MB
Telegaonkar, Intranasal delivery- An approach to bypass the blood brain
barrier, Ind J Pharm 2004 (click here) - PDF 0.6 MB
Wolfe,
Intranasal Medications in EMS, JEMS 2003 (click here) - PDF 0.33 MB
Pires, Intranasal drug delivery - How why what for -extensive review, J
Pharm Pharmaceut Sci 2009
Alsarra, Vesicular systems for IN delivery 2009.pdf
Mercus, Influence of head postion and anatomy on nasal drug deposition,
Rhinology 2006.pdf
Chris
Colwell MD - The Nose Knows: Intranasal Medication options are growing
(presentation at Gathering of Eagles EMS conference Feb 2011)
Warrington, Use of intranasal medications in pediatrics, Pharmacology
Update on Orthopedics supersite 2011
Callopy and Snyder, Intranasal drug delivery in EMS. EMS today May 2011
Wolfe and Braude, Intranasal medication delivery for children: A brief
review and update. Pediatrics 2010
Nose Brain pathway
Ying, The nose may help the brain: Intranasal drug delivery for treating
neurologic diseases, Future Neurology 2008 (click here) - PDF 1.4 MB
Nosy neuroprotection - discussion of the nose brain pathway
Hanson, IN drugs for neurodegenerative disorders, Policy Holder
Advocate.pdf
Talegaonkar, Intranasal delivery - An approach to bypass the blood brain
barrier, Indian J Pharm 2004.pdf
Westin, Olfactory transfer of analgesic drugs after nasal
administration, Thesis paper 2007
Putheti, Nasal drug delivery in biotech, e-Journal Science 2009.pdf
Therapeutic
Intranasal Drug Delivery