Seizing child recieving IN treatmentTherapeutic Intranasal Drug Delivery

Needleless treatment options for medical problems

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Featured new articles and web site sections related to intranasal drug delivery - Contents:

January-September 2016 (click for link)

Smith, D., H. Cheek, et al. (2016). "Lidocaine Pretreatment Reduces the Discomfort of Intranasal Midazolam Administration: A randomized, double-blind, placebo-controlled trial." Acad Emerg Med.

Crawford, D. (2016). "Implementation of Intranasal Midazolam for Prolonged Seizures in a Child Neurology Practice." J Neurosci Nurs.

Cozzi, G., S. Lega, et al. (2016). "Intranasal Dexmedetomidine Sedation as Adjuvant Therapy in Acute Asthma Exacerbation With Marked Anxiety and Agitation." Ann Emerg Med.

Fenster, D. B., P. S. Dayan, et al. (2016). "Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage." Pediatr Emerg Care.

Kurien, T., K. R. Price, et al. (2016). "Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department: a 2.5-year study." Bone Joint J 98-B(1): 131-136.

Murphy, A. P., M. Hughes, et al. (2016). "Intranasal fentanyl for the prehospital management of acute pain in children." Eur J Emerg Med.

Fisher, R., D. O'Donnell, et al. (2016). "Police Officers Can Safely and Effectively Administer Intranasal Naloxone." Prehosp Emerg Care: 1-6.

Baier, N. M., S. S. Mendez, et al. (2016). "Intranasal dexmedetomidine: an effective sedative agent for electroencephalogram and auditory brain response testing." Paediatr Anaesth 26(3): 280-285.


October-December 2015 (click for link)

Kavanagh, P. L., P. G. Sprinz, et al. (2015). "Improving the Management of Vaso-Occlusive Episodes in the Pediatric Emergency Department." Pediatrics 136(4): e1016-1025.

April-Sept 2015 (click for link)

Over the counter nasal naloxone!!

Graudins, A., R. Meek, et al. (2015). "The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: a randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries." Ann Emerg Med 65(3): 248-254 e241.

Schacherer, N. M., D. E. Ramirez, et al. (2015). "Expedited Delivery of Pain Medication for Long-Bone Fractures Using an Intranasal Fentanyl Clinical Pathway." Pediatr Emerg Care.

Belkouch, A., S. Zidouh, et al. (2015). "Does intranasal fentanyl provide efficient analgesia for renal colic in adults?" Pan Afr Med J 20: 407.

Dolatabadi, A. A., M. Shojaee, et al. (2015). "Intranasal sufentanil versus intravenous morphine sulfate in pain management of patients with extremity trauma." Iranian Journal of Emergency Medicine 3(2): 116-121.

Montero, J. V., E. M. Nieto, et al. (2015). "Intranasal midazolam for the emergency management of hypercyanotic spells in tetralogy of fallot." Pediatr Emerg Care 31(4): 269-271.

Brigo, F., R. Nardone, et al. (2015). "Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis." Epilepsy Behav.

Caron, E., C. E. Wheless, et al. (2015). "The charges for seizures in the pediatric emergency room: a single center study." Pediatr Neurol 52(5): 517-520.

Rando, J., D. Broering, et al. (2015). "Intranasal naloxone administration by police first responders is associated with decreased opioid overdose deaths." Am J Emerg Med.

January-March 2015 (click for link)

Fleet J, Belan I, Jones M, Ullah S, Cyna A. A comparison of fentanyl with pethidine for pain relief during childbirth: a randomised controlled trial. BJOG : an international journal of obstetrics and gynaecology 2015.

Mukherjee A, Das A, Basunia SR, Chattopadhyay S, Kundu R, Bhattacharyya R. Emergence agitation prevention in paediatric ambulatory surgery: A comparison between intranasal Dexmedetomidine and Clonidine. Journal of research in pharmacy practice 2015;4:24-30.

Riediger C, Haschke M, Bitter C, et al. The analgesic effect of combined treatment with intranasal S-ketamine and intranasal midazolam compared with morphine patient-controlled analgesia in spinal surgery patients: a pilot study. J Pain Res 2015;8:87-94.

April-December 2014 (click for link)

Sabzghabaee, A. M., N. Eizadi-Mood, et al. (2014). "Naloxone therapy in opioid overdose patients: intranasal or intravenous? A randomized clinical trial." Arch Med Sci 10(2): 309-314.

Karlsen, A.P., et al., Safety of intranasal fentanyl in the out-of-hospital setting: a prospective observational study. Ann Emerg Med, 2014. 63(6): p. 699-703.

Tsze, D.S., et al., Treatment of tetralogy of Fallot hypoxic spell with intranasal fentanyl. Pediatrics, 2014. 134(1): p. e266-9.

Wagner, K. D., P. J. Davidson, et al. (2014). ""I felt like a superhero": the experience of responding to drug overdose among individuals trained in overdose prevention." Int J Drug Policy 25(1): 157-165.

Weiner, S. G., P. M. Mitchell, et al. (2014). "Use of intranasal naloxone by basic life support providers." Ann Emerg Med 64(4): S52 (Abstract 144).

January-March 2014 (click for link)

Baleine, J., C. Milesi, et al. (2014). "Intubation in the delivery room: experience with nasal midazolam." Early Hum Dev 90(1): 39-43.

Buonsenso, D., G. Barone, et al. (2014). "Utility of intranasal Ketamine and Midazolam to perform gastric aspirates in children: a double-blind, placebo controlled, randomized study." BMC Pediatr 14(1): 67.

Wang, S. S., M. Z. Zhang, et al. (2014). "The sedative effects and the attenuation of cardiovascular and arousal responses during anesthesia induction and intubation in pediatric patients: a randomized comparison between two different doses of preoperative intranasal dexmedetomidine." Paediatr Anaesth 24(3): 275-281.

October-December 2013 (click for link)

Andolfatto, G., E. Willman, et al. (2013). "Intranasal Ketamine for Analgesia in the Emergency Department: A Prospective Observational Series." Acad Emerg Med 20(10): 1050-1054.

Gracia, M. R., L. C. Hortelano, et al. (2013). "Intoxicación  accidental  por  fentanilo intranasal." Anales de Pediatria In press.

Mitra, S., S. Kazal, et al. (2013). "Intranasal clonidine vs midazolam as premedication in children: A randomized controlled trial." Indian Pediatr (In press).

Sharma, R. and R. Harish (2013). "Comparative study of the efficacy of intranasal midazolam vs intravenous midazolam in convulsing neonates and children." RRJMHS 2(4): 54-57.

April - September 2013 (click for link)

Humphries, L. K. and L. S. Eiland (2013). "Treatment of acute seizures: is intranasal midazolam a viable option?" J Pediatr Pharmacol Ther 18(2): 79-87.

Johansson, J., J. Sjoberg, et al. (2013). "Prehospital analgesia using nasal administration of S-ketamine--a case series." Scand J Trauma Resusc Emerg Med 21: 38.

January-March 2013 (click for link)

EMS teaching slide sets with audio embedded.

Articles reviewed:

Etteri, M. and A. Bellone, Intranasal Fentanyl for analgesia in adults with acute renal colic. Emergency Care Journal, 2012. 8(2): p. 13-18.

Coffin, P.O. and S.D. Sullivan, Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Ann Intern Med, 2013. 158(1): p. 1-9.

Compton, W.M., et al., Expanded access to opioid overdose intervention: research, practice, and policy needs. Ann Intern Med, 2013. 158(1): p. 65-6.

Yeaman F, Oakley E, Meek R, Graudins A. Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: A pilot study. Emerg Med Australas 2013;25:161-7.

October-December 2012 (Click for link to abstracts, editorial and PubMed Link)

Intranasal Ketamine: New Section of the web site reviewing intranasal Ketamine for pain and for sedation - written due to increasing interest on the topic

New Slide sets: Multiple new slides sets related to intranasal drug delivery in EMS, ER, Rural care, Trauma, Hospice and safe injection are posted following a recent lecture tour presenting these topics.

July-Sept 2012 (Click for link to abstracts, editorial and PubMed link)

Stephen, R., E. Lingenfelter, et al. (2012). "Intranasal sufentanil provides adequate analgesia for emergency department patients with extremity injuries." J Opioid Manag 8(4): 237-241.

Thakker, A. and P. Shanbag (2012). "A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures." J Neurol.

Tsze, D. S., D. W. Steele, et al. (2012). "Intranasal Ketamine for Procedural Sedation in Pediatric Laceration Repair: A Preliminary Report." Pediatr Emerg Care 28(8): 767-770.

Sibley, T., R. Jacobsen, et al. (2012). "Successful Administration of Intranasal Glucagon in the Out-of-Hospital Environment." Prehosp Emerg Care.

Harlos, M. S., S. Stenekes, et al. (2012). "Intranasal Fentanyl in the Palliative Care of Newborns and Infants." J Pain Symptom Manage.


April - June 2012 (Click for abstracts, editorial and PubMed Link)

Steenblik, J., et al., Intranasal sufentanil for the treatment of acute pain in a winter resort clinic. Am J Emerg Med, 2012.

January - March 2012 (Click for abstracts, editorial and PubMed Link)

Anderson, M., et al., Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers. Eur J Clin Pharmacol, 2012. 68(2): p. 155-9.

Silbergleit, R., et al., Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med, 2012. 366(7): p. 591-600.

Hirsch, L.J., Intramuscular versus intravenous benzodiazepines for prehospital treatment of status epilepticus. N Engl J Med, 2012. 366(7): p. 659-60.

Kawanda, L., et al., Sedation with intranasal midazolam of Angolan children undergoing invasive procedures. Acta Paediatr, 2012. 101(7): p. e296-8.

Javadzadeh, M., K. Sheibani, et al. (2012). "Intranasal midazolam compared with intravenous diazepam in patients suffering from acute seizure: A randomized controlled trial." Iran J Pediatr 22(1): 1-8.

Hippard, H. K., K. Govindan, et al. (2012). "Postoperative analgesic and behavioral effects of intranasal fentanyl, intravenous morphine, and intramuscular morphine in pediatric patients undergoing bilateral myringotomy and placement of ventilating tubes." Anesth Analg 115(2): 356-363.

October - December 2011 (Click for abstracts, editorial and PubMed Link)

Pestieau, S.R., et al., The effect of dexmedetomidine during myringotomy and pressure-equalizing tube placement in children. Paediatr Anaesth, 2011. 21(11): p. 1128-35.

Antonio, C., J. Zurek, et al. (2011). "Reducing the pain of intranasal drug administration." Pediatr Dent 33(5): 415-419.

Pandey, R. K., S. K. Bahetwar, et al. (2011). "A comparative evaluation of drops versus atomized administration of intranasal ketamine for the procedural sedation of young uncooperative pediatric dental patients: a prospective crossover trial." J Clin Pediatr Dent 36(1): 79-84.


July - September 2011 (Click for abstracts, editorial and PubMed Link)

Klein, E.J., et al., A Randomized Clinical Trial Comparing Oral, Aerosolized Intranasal, and Aerosolized Buccal Midazolam. Ann Emerg Med, 2011.

Mudd, S., Intranasal Fentanyl for Pain Management in Children: A Systematic Review of the Literature. J Pediatr Health Care, 2011. 25(5): p. 316-22

Cheung, C.W., et al., Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth, 2011. 107(3): p. 430-7.


 April - June 2011 (Click for abstracts, editorial and PubMed link)

Carpuject concept (not an article - just an idea very pertinent to this web site topic)

Borland, M., S. Milsom, et al. (2011). "Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: A randomized controlled trial." Emerg Med Australas 23(2): 202-208.

Lundeberg, S. and J. A. Roelofse (2011). "Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice." Paediatr Anaesth 21(3): 274-279.

Prommer, E. and L. Thompson (2011). "Intranasal Fentanyl for pain control: current status with a focus on patient considerations." Patient Preference and Adherence (open access) 5: 157-164.

January - March 2011 (Click for abstracts, editorial and PubMed link)

Wolfe, T. R. and D. A. Braude (2010). "Intranasal medication delivery for children: a brief review and update." Pediatrics 126(3): 532-537.

Chiaretti, A., G. Barone, et al. (2011).  Intranasal lidocaine and midazolam for procedural sedation in children. Arch Dis Child 96:160-163

Arya, R., S. Gulati, et al. (2011). "Intranasal versus intravenous lorazepam for control of acute seizures in children: A randomized open-label study." Epilepsia

Bendall, J. C., P. M. Simpson, et al. (2011). "Effectiveness of Prehospital Morphine, Fentanyl, and Methoxyflurane in Pediatric Patients." Prehosp Emerg Care.

Johnston, S., G. J. Wilkes, et al. (2011). "Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service." Emerg Med J 28(1): 57-63.

Reid, C., R. Hatton, and P. Middleton, Case report: prehospital use of intranasal ketamine for paediatric burn injury. Emerg Med J, 2011. 28(4): p. 328-9.