Therapeutic
Intranasal Drug DeliveryFeatured new articles and web site sections related to intranasal drug delivery - Contents:
January - December 2020 (Click for link)
Bouida, W., K. Bel Haj Ali, et al. (2020). "Effect on Opioids Requirement of Early Administration of Intranasal Ketamine for Acute Traumatic Pain." Clin J Pain 36(6): 458-462.
Crawshaw, A. A. and H. R. Cock (2020). "Medical management of status epilepticus: Emergency room to intensive care unit." Seizure 75: 145-152.
Huebinger, R. M., H. Q. Zaidi, et al. (2020). "Retrospective Study of
Midazolam Protocol for Prehospital Behavioral Emergencies." West J
Emerg Med 21(3): 677-683.
January - December 2019 (Click for link)
Akkan, S., S. K. Corbacioglu, et al. (2019). "Evaluating Effectiveness of Nasal Compression With Tranexamic Acid Compared With Simple Nasal Compression and Merocel Packing: A Randomized Controlled Trial." Ann Emerg Med 74(1): 72-78.
Dietze, P., M. Jauncey, et al. (2019). "Effect of Intranasal vs
Intramuscular Naloxone on Opioid Overdose: A Randomized Clinical Trial."
JAMA Netw Open 2(11):
e1914977.
Pruyn, S., J. Frey, et al. (2019). "Quality Assessment of Expired
Naloxone Products from First-Responders' Supplies." Prehosp Emerg
Care 23(5): 647-653.
Andolfatto, G., K. Innes, et al. (2019). "Prehospital Analgesia With
Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in
Adults." Ann Emerg Med 74(2):
241-250.
Blancher, M., M. Maignan,
et al. (2019). "Intranasal sufentanil versus intravenous morphine for
acute severe trauma pain: A double-blind randomized non-inferiority
study." PLoS Med 16(7):
e1002849.
Lemoel, F., J. Contenti, et al. (2019). "Intranasal sufentanil given in
the emergency department triage zone for severe acute traumatic pain: a
randomized double-blind controlled trial." Intern Emerg Med
14(4): 571-579.
Sin,
B., I. Jeffrey, et al. (2019). "Intranasal Sufentanil Versus Intravenous
Morphine for Acute Pain in the Emergency Department: A Randomized Pilot
Trial." J Emerg Med 56(3):
301-307.
Frey, T. M., T. A. Florin, et al. (2019). "Effect of Intranasal Ketamine
vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The
PRIME Randomized Clinical Trial." JAMA Pediatr
173(2): 140-146.
Mozafari, J., M. Maleki Verki, et al. (2019). "Comparing intranasal
ketamine with intravenous fentanyl in reducing pain in patients with
renal colic: A double-blind randomized clinical trial." Am J Emerg
Med.
Nazemian, N., M. Torabi, et al. (2019). "Atomized intranasal vs
intravenous fentanyl in severe renal colic pain management: A randomized
single-blinded clinical trial." Am J Emerg Med: 158483.
Bregstein, J. S., A. M. Wagh, et al. (2019).
"Intranasal Lorazepam for Treatment of Severe Agitation in a Pediatric
Behavioral Health Patient in the Emergency Department." Ann Emerg Med.
Khalil, W. and N. Raslan (2019). "The effectiveness of topical lidocaine
in relieving pain related to intranasal midazolam sedation: a
randomized, placebo-controlled clinical trial." Quintessence Int:
2-7.
Malia, L., V. M. Laurich, et al. (2019). "Adverse events and
satisfaction with use of intranasal midazolam for emergency department
procedures in children." Am J Emerg Med
37(1): 85-88.
Ryan, P. M., A. J. Kienstra, et al. (2019). "Safety and effectiveness of
intranasal midazolam and fentanyl used in combination in the pediatric
emergency department." Am J Emerg Med
37(2): 237-240.
Gu,
H. B., Y. A. Song, et al. (2019). "Median Effective Dose of Intranasal
Dexmedetomidine for Transthoracic Echocardiography in Children with
Kawasaki Disease Who Have a History of Repeated Sedation." Med Sci
Monit 25: 381-388.
Yang, F., S. Li, et al. (2019). "Fifty Percent Effective Dose of
Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography
in Children With Cyanotic and Acyanotic Congenital Heart Disease." J
Cardiothorac Vasc Anesth.
Liu,
H., M. Sun, et al. (2019). "Determination of the 90% effective dose of
intranasal dexmedetomidine for sedation during electroencephalography in
children." Acta Anaesthesiol Scand
63(7): 847-852.
Lei,
H., L. Chao, et al. (2019). "Incidence and risk factors of bradycardia
in pediatric patients undergoing intranasal dexmedetomidine sedation."
Acta Anaesthesiol Scand.
Yang, F., Y. Liu, et al. (2019). "Analysis of 17 948 pediatric patients
undergoing procedural sedation with a combination of intranasal
dexmedetomidine and ketamine." Paediatr Anaesth
29(1): 85-91.
Owusu, K. A., M. B. Dhakar, et al. (2019). "Comparison of intranasal
midazolam versus intravenous lorazepam for seizure termination and
prevention of seizure clusters in the adult epilepsy monitoring unit."
Epilepsy Behav 98(Pt
A): 161-167.
January - December 2018 (Click for link)
Frey, T. M., T. A. Florin, et al. (2018). "Effect of Intranasal Ketamine
vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The
PRIME Randomized Clinical Trial." JAMA Pediatr.
Kelly, G. S., R. W. Stewart, et al. (2018). "Intranasal fentanyl
improves time to analgesic delivery in sickle cell pain crises." Am J
Emerg Med 36(7):
1305-1307.
Nunley, S., P. Glynn, et al. (2018). "Healthcare Utilization
Characteristics for Intranasal Midazolam Versus Rectal Diazepam." J
Child Neurol 33(2):
158-163.
Ostendorf, A. P., K. Merison, et al. (2018). "Decreasing Seizure
Treatment Time Through Quality Improvement Reduces Critical Care
Utilization." Pediatr Neurol
85: 58-66.
Milesi, C., J. Baleine, et al. (2018). "Nasal midazolam vs ketamine for
neonatal intubation in the delivery room: a randomised trial." Arch
Dis Child Fetal Neonatal Ed
103(3): F221-F226.
Olgun, G. and
M. H. Ali (2018). "Use of Intranasal Dexmedetomidine as a Solo Sedative
for MRI of Infants." Hosp Pediatr.
Reynolds, J. and D. J. Sedillo (2018). "The Evolving Role of Intranasal
Dexmedetomidine for Pediatric Procedural Sedation." Hosp Pediatr.
January - December 2017 (click for link)
Adelgais, K. M., A. Brent, et al. (2017).
"Intranasal Fentanyl and Quality of Pediatric Acute Care." J Emerg
Med.
Farnia, M. R., A. Jalali, et al. (2017). "Comparison of intranasal
ketamine versus IV morphine in reducing pain in patients with renal
colic." Am J Emerg Med 35(3):
434-437.
Mellion, S. A., D. Bourne, et al. (2017). "Evaluating Clinical
Effectiveness and Pharmacokinetic Profile of Atomized Intranasal
Midazolam in Children Undergoing Laceration Repair." J Emerg Med
53(3): 397-404.
Reynolds, S. L., K. K. Bryant, et al. (2017).
"Randomized Controlled Feasibility Trial of Intranasal Ketamine Compared
to Intranasal Fentanyl for Analgesia in Children with Suspected
Extremity Fractures." Acad Emerg Med.
Milesi, C., J. Baleine, et al. (2017). "Nasal midazolam vs ketamine for
neonatal intubation in the delivery room: a randomised trial." Arch
Dis Child Fetal Neonatal Ed.
Schrier, L., R. Zuiker, et al. (2017). "Pharmacokinetics and
pharmacodynamics of a new highly concentrated intranasal midazolam
formulation for conscious sedation." Br J Clin Pharmacol
83(4): 721-731.
Smith, D., H. Cheek, et al. (2017). "Lidocaine Pretreatment Reduces the
Discomfort of Intranasal Midazolam Administration: A Randomized,
Double-blind, Placebo-controlled Trial." Acad Emerg Med
24(2): 161-167.
Sanchez Fernandez, I., M. Gainza-Lein, et al. (2017). "Nonintravenous
rescue medications for pediatric status epilepticus: A
cost-effectiveness analysis." Epilepsia
58(8): 1349-1359.
Bailey, A. M., R. A. Baum, et al. (2017). "Review of Intranasally
Administered Medications for Use in the Emergency Department." J
Emerg Med 53(1): 38-48.
McBride, D. L. (2017). "Emergency Departments Increasingly Administering
Medications through the Nose." J Pediatr Nurs.
Rech,
M. A., B. Barbas, et al. (2017). "When to Pick the Nose: Out-of-Hospital
and Emergency Department Intranasal Administration of Medications."
Ann Emerg Med 70(2):
203-211.
Nemeth, M., N. Jacobsen, et al. (2017). "Intranasal Analgesia and
Sedation in Pediatric Emergency Care-A Prospective Observational Study
on the Implementation of an Institutional Protocol in a Tertiary
Children's Hospital." Pediatr Emerg Care.
Tsze,
D. S., M. Ieni, et al. (2017). "Optimal Volume of Administration of
Intranasal Midazolam in Children: A Randomized Clinical Trial." Ann
Emerg Med 69(5): 600-609.
Weiner, S. G., P. M.
Mitchell, et al. (2017). "Use of Intranasal Naloxone by Basic Life
Support Providers." Prehosp Emerg Care
21(3): 322-326.
January-December 2016 (click for link)
Smith, D., H. Cheek, et al. (2016). "Lidocaine Pretreatment Reduces the
Discomfort of Intranasal Midazolam Administration: A randomized,
double-blind, placebo-controlled trial." Acad Emerg Med.
Crawford, D. (2016). "Implementation of Intranasal Midazolam for
Prolonged Seizures in a Child Neurology Practice." J Neurosci Nurs.
Cozzi, G., S. Lega, et al. (2016). "Intranasal Dexmedetomidine Sedation
as Adjuvant Therapy in Acute Asthma Exacerbation With Marked Anxiety and
Agitation." Ann Emerg Med.
Fenster, D. B., P. S. Dayan, et al. (2016). "Randomized Trial of
Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and
Drainage." Pediatr Emerg Care.
Kurien, T., K. R. Price, et al. (2016). "Manipulation and reduction of
paediatric fractures of the distal radius and forearm using intranasal
diamorphine and 50% oxygen and nitrous oxide in the emergency
department: a 2.5-year study." Bone Joint J 98-B(1): 131-136.
Murphy, A. P., M. Hughes, et al. (2016). "Intranasal fentanyl for the
prehospital management of acute pain in children." Eur J Emerg Med.
Fisher, R., D. O'Donnell, et al. (2016). "Police Officers Can Safely and
Effectively Administer Intranasal Naloxone." Prehosp Emerg Care:
1-6.
Baier, N. M., S. S. Mendez, et al. (2016). "Intranasal dexmedetomidine:
an effective sedative agent for electroencephalogram and auditory brain
response testing." Paediatr Anaesth 26(3): 280-285.
October-December 2015 (click for link)
Kavanagh, P. L., P. G. Sprinz, et
al. (2015). "Improving the Management of Vaso-Occlusive Episodes in the
Pediatric Emergency Department." Pediatrics
136(4): e1016-1025.
April-Sept 2015 (click for link)
Over the counter nasal naloxone!!
Graudins, A., R. Meek, et al. (2015). "The PICHFORK (Pain in Children
Fentanyl or Ketamine) trial: a randomized controlled trial comparing
intranasal ketamine and fentanyl for the relief of moderate to severe
pain in children with limb injuries." Ann Emerg Med
65(3): 248-254 e241.
Belkouch, A., S. Zidouh, et al. (2015). "Does intranasal fentanyl provide
efficient analgesia for renal colic in adults?" Pan Afr Med J
20: 407.
Montero, J. V., E. M. Nieto, et al. (2015). "Intranasal midazolam for the
emergency management of hypercyanotic spells in tetralogy of fallot."
Pediatr Emerg Care 31(4):
269-271.
Brigo, F., R. Nardone, et al. (2015). "Nonintravenous midazolam versus
intravenous or rectal diazepam for the treatment of early status
epilepticus: A systematic review with meta-analysis." Epilepsy Behav.
Caron, E., C. E. Wheless, et al. (2015). "The charges for seizures in the
pediatric emergency room: a single center study." Pediatr Neurol
52(5): 517-520.
Rando, J., D. Broering, et al. (2015). "Intranasal naloxone administration
by police first responders is associated with decreased opioid overdose
deaths." Am J Emerg Med.
January-March 2015 (click for link)
Fleet J, Belan I, Jones M, Ullah S, Cyna A. A comparison of fentanyl with pethidine for pain relief during childbirth: a randomised controlled trial. BJOG : an international journal of obstetrics and gynaecology 2015.
Mukherjee A, Das A, Basunia SR, Chattopadhyay S, Kundu R, Bhattacharyya R. Emergence agitation prevention in paediatric ambulatory surgery: A comparison between intranasal Dexmedetomidine and Clonidine. Journal of research in pharmacy practice 2015;4:24-30.
Riediger C, Haschke M, Bitter C, et al. The analgesic effect of combined treatment with intranasal S-ketamine and intranasal midazolam compared with morphine patient-controlled analgesia in spinal surgery patients: a pilot study. J Pain Res 2015;8:87-94.
April-December 2014 (click for link)
Sabzghabaee, A. M., N. Eizadi-Mood, et al. (2014). "Naloxone therapy in
opioid overdose patients: intranasal or intravenous? A randomized
clinical trial." Arch Med Sci
10(2): 309-314.
Karlsen, A.P., et al., Safety of intranasal fentanyl in the out-of-hospital setting: a prospective observational study. Ann Emerg Med, 2014. 63(6): p. 699-703.
Tsze, D.S., et al., Treatment of
tetralogy of Fallot hypoxic spell with intranasal fentanyl. Pediatrics,
2014. 134(1): p. e266-9.
Wagner, K. D., P. J. Davidson, et al. (2014). ""I felt like a superhero":
the experience of responding to drug overdose among individuals trained
in overdose prevention." Int J Drug Policy
25(1): 157-165.
Weiner, S. G., P. M. Mitchell, et al. (2014). "Use of intranasal naloxone
by basic life support providers." Ann Emerg Med
64(4): S52 (Abstract 144).
January-March 2014 (click for link)
Baleine, J., C. Milesi, et al. (2014). "Intubation
in the delivery room: experience with nasal midazolam." Early
Hum Dev 90(1): 39-43.
Buonsenso, D., G. Barone, et al. (2014). "Utility of intranasal Ketamine
and Midazolam to perform gastric aspirates in children: a double-blind,
placebo controlled, randomized study." BMC Pediatr
14(1): 67.
Wang, S. S., M. Z. Zhang, et
al. (2014). "The sedative effects and the attenuation of cardiovascular
and arousal responses during anesthesia induction and intubation in
pediatric patients: a randomized comparison between two different doses
of preoperative intranasal dexmedetomidine." Paediatr Anaesth
24(3): 275-281.
October-December 2013 (click for link)
Andolfatto, G., E. Willman, et al. (2013). "Intranasal Ketamine for
Analgesia in the Emergency Department: A Prospective Observational
Series." Acad Emerg Med 20(10):
1050-1054.
Gracia, M. R., L. C. Hortelano, et al. (2013). "Intoxicación
accidental por
fentanilo intranasal." Anales de Pediatria
In press.
Mitra, S., S. Kazal, et al. (2013). "Intranasal clonidine vs midazolam as
premedication in children: A randomized controlled trial." Indian
Pediatr (In press).
Sharma, R. and R. Harish
(2013). "Comparative study of the efficacy of intranasal midazolam vs
intravenous midazolam in convulsing neonates and children." RRJMHS
2(4): 54-57.
April - September 2013 (click for link)
Humphries, L. K. and L. S. Eiland (2013). "Treatment of acute seizures: is
intranasal midazolam a viable option?" J Pediatr Pharmacol Ther
18(2): 79-87.
Johansson, J., J. Sjoberg, et al. (2013). "Prehospital analgesia using
nasal administration of S-ketamine--a case series." Scand J Trauma
Resusc Emerg Med 21: 38.
January-March 2013 (click for link)
EMS teaching slide sets with audio embedded.
Articles reviewed:
Etteri, M. and A. Bellone,
Intranasal Fentanyl for analgesia in adults with acute renal colic.
Emergency Care Journal, 2012. 8(2): p. 13-18.
Coffin, P.O. and S.D. Sullivan,
Cost-effectiveness of distributing naloxone to heroin users for lay
overdose reversal. Ann Intern Med, 2013. 158(1): p. 1-9.
Compton, W.M., et al.,
Expanded access to opioid overdose intervention: research, practice, and
policy needs. Ann Intern Med, 2013. 158(1): p. 65-6.
Yeaman F, Oakley E, Meek R, Graudins A. Sub-dissociative dose intranasal
ketamine for limb injury pain in children in the emergency department: A
pilot study. Emerg Med Australas 2013;25:161-7.
October-December 2012 (Click for link to abstracts, editorial and PubMed Link)
Intranasal Ketamine: New Section of the web site reviewing intranasal Ketamine for pain and for sedation - written due to increasing interest on the topic
New Slide sets: Multiple new slides sets related to intranasal drug delivery in EMS, ER, Rural care, Trauma, Hospice and safe injection are posted following a recent lecture tour presenting these topics.
July-Sept 2012 (Click for link to abstracts, editorial and PubMed link)
Stephen, R., E. Lingenfelter, et al. (2012). "Intranasal sufentanil
provides adequate analgesia for emergency department patients with
extremity injuries." J Opioid Manag
8(4): 237-241.
Thakker, A. and P. Shanbag (2012). "A randomized controlled trial of
intranasal-midazolam versus intravenous-diazepam for acute childhood
seizures." J Neurol.
Tsze,
D. S., D. W. Steele, et al. (2012). "Intranasal Ketamine for Procedural
Sedation in Pediatric Laceration Repair: A Preliminary Report."
Pediatr Emerg Care 28(8):
767-770.
Sibley, T., R. Jacobsen, et al. (2012). "Successful Administration of
Intranasal Glucagon in the Out-of-Hospital Environment." Prehosp
Emerg Care.
Harlos, M. S., S. Stenekes, et al. (2012). "Intranasal Fentanyl in the
Palliative Care of Newborns and Infants." J Pain Symptom Manage.
April - June 2012 (Click for abstracts, editorial and PubMed Link)
Steenblik, J., et al., Intranasal sufentanil for the treatment of acute pain in a winter resort clinic. Am J Emerg Med, 2012.
January - March 2012 (Click for abstracts, editorial and PubMed Link)
Anderson, M., et al.,
Pharmacokinetics of buccal and intranasal lorazepam in healthy adult
volunteers. Eur J Clin Pharmacol, 2012.
68(2): p. 155-9.
Silbergleit, R., et al.,
Intramuscular versus intravenous therapy for prehospital status
epilepticus. N Engl J Med, 2012.
366(7): p. 591-600.
Hirsch, L.J.,
Intramuscular versus intravenous benzodiazepines for prehospital
treatment of status epilepticus. N Engl J Med, 2012.
366(7): p. 659-60.
Kawanda, L., et al., Sedation
with intranasal midazolam of Angolan children undergoing invasive
procedures. Acta Paediatr, 2012.
101(7): p. e296-8.
Javadzadeh, M., K. Sheibani, et al. (2012). "Intranasal midazolam compared
with intravenous diazepam in patients suffering from acute seizure: A
randomized controlled trial." Iran J Pediatr
22(1): 1-8.
Hippard, H. K., K. Govindan, et
al. (2012). "Postoperative analgesic and behavioral effects of
intranasal fentanyl, intravenous morphine, and intramuscular morphine in
pediatric patients undergoing bilateral myringotomy and placement of
ventilating tubes." Anesth Analg
115(2): 356-363.
October - December 2011 (Click for abstracts, editorial and PubMed Link)
Pestieau, S.R., et al., The effect of dexmedetomidine during myringotomy and pressure-equalizing tube placement in children. Paediatr Anaesth, 2011. 21(11): p. 1128-35.
Antonio, C., J. Zurek, et al.
(2011). "Reducing the pain of intranasal drug administration."
Pediatr Dent 33(5):
415-419.
Pandey, R. K., S. K. Bahetwar, et al. (2011). "A comparative evaluation of
drops versus atomized administration of intranasal ketamine for the
procedural sedation of young uncooperative pediatric dental patients: a
prospective crossover trial." J Clin Pediatr Dent
36(1): 79-84.
July - September 2011 (Click for abstracts, editorial and PubMed Link)
Klein, E.J., et al., A Randomized Clinical Trial Comparing Oral, Aerosolized Intranasal, and Aerosolized Buccal Midazolam. Ann Emerg Med, 2011.
Mudd, S., Intranasal Fentanyl for Pain Management in Children: A Systematic Review of the Literature. J Pediatr Health Care, 2011. 25(5): p. 316-22
Cheung, C.W., et al., Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth, 2011. 107(3): p. 430-7.
April - June 2011 (Click for abstracts, editorial and PubMed link)
Carpuject concept (not an article - just an idea very pertinent to this web site topic)
Borland, M., S. Milsom, et al. (2011). "Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: A randomized controlled trial." Emerg Med Australas 23(2): 202-208.
Lundeberg, S. and J. A. Roelofse (2011). "Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice." Paediatr Anaesth 21(3): 274-279.
Prommer, E. and L. Thompson (2011). "Intranasal Fentanyl for pain control: current status with a focus on patient considerations." Patient Preference and Adherence (open access) 5: 157-164.
January - March 2011 (Click for abstracts, editorial and PubMed link)
Wolfe, T. R. and D. A. Braude (2010). "Intranasal medication delivery for children: a brief review and update." Pediatrics 126(3): 532-537.
Chiaretti, A., G. Barone, et al. (2011). Intranasal lidocaine and midazolam for procedural sedation in children. Arch Dis Child 96:160-163
Arya, R., S. Gulati, et al. (2011). "Intranasal versus intravenous lorazepam for control of acute seizures in children: A randomized open-label study." Epilepsia
Bendall, J. C., P. M. Simpson, et al. (2011). "Effectiveness of Prehospital Morphine, Fentanyl, and Methoxyflurane in Pediatric Patients." Prehosp Emerg Care.
Johnston, S., G. J. Wilkes, et al. (2011). "Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service." Emerg Med J 28(1): 57-63.
Reid, C., R. Hatton, and P. Middleton, Case report: prehospital use of intranasal ketamine for paediatric burn injury. Emerg Med J, 2011. 28(4): p. 328-9.
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